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AHRQ Safety Program for HAI Prevention

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About the AHRQ Safety Program for HAI Prevention


The Agency for Healthcare Research and Quality (AHRQ), in conjunction with NORC at the University of Chicago and the Johns Hopkins University, created the AHRQ Safety Program for Healthcare-Associated Infection (HAI) Prevention to implement a bundle of recently updated evidence-based infection prevention toolkits designed to measurably decrease HAIs in intensive care units (ICUs) and non-ICUs across the United States. The AHRQ Safety Program for HAI Prevention builds on AHRQ’s pioneering work using Comprehensive Unit-based Safety Program (CUSP) methods to reduce three common HAIs: central line-associated bloodstream infections, catheter-associated urinary tract infections, and ventilator-associated pneumonia and ventilator-associated events. This program aims to refine the current AHRQ toolkits for preventing these HAIs to ensure they meet the needs of our current healthcare environment.

HAIs are a major cause of illness in the United States, affecting about 3 percent of all hospitalized patients and resulting in as many as 700,000 infections per year.[1] HAI prevention efforts are challenged by (1) the COVID-19 pandemic, (2) the need for updated evidence and toolkits, and (3) antimicrobial resistance. The program aims to enhance the utility of existing HAI prevention toolkits by updating them with the latest evidence and refining them using lessons learned from their real-world implementation.

[1] Centers for Disease Control and Prevention. HAIs: Reports and Data. Updated November 25, 2024. Accessed October 2024. HAIs: Reports and Data | HAIs | CDC.

Apply Now for These Cohorts


Central Line-Associated Bloodstream Infections (CLABSI)


Apply to the Program


Enrollment is currently open.

For more information about the program, please visit the Program FAQs or Join the Program.

Upcoming Informational Webinars


Please select the corresponding link below to register and attend an upcoming informational webinar to learn more about the program.

Date Time Registration Link
Thurs, May 8, 2025 11—11:30 a.m. ET https://norc.zoom.us/webinar/register/WN_lxPzqdUFSeSTSSrif1UB9Q
Wed, May 14, 2025 2—2:30 p.m. ET https://norc.zoom.us/webinar/register/WN_HnmjtwPjSJeuUlG3czKygg
Thurs, Jun 5, 2025 10:30—11 a.m. ET https://norc.zoom.us/webinar/register/WN_L0pxgQ0ZSdOzscz03yB4OQ
Wed, Jun 11, 2025 1:30—2 p.m. ET https://norc.zoom.us/webinar/register/WN_dhSfOxjfRTOpzUbbRLXyMw
Tues, Jun 24, 2025 Noon—12:30 p.m. ET https://norc.zoom.us/webinar/register/WN_HM-TI_2STdCoTlrhXzumhg

CLABSI Informational Webinar Materials

  • Webinar recording
  • Webinar transcript
  • Webinar slides

Program Cohorts


Central Line-Associated Bloodstream Infections (CLABSI): Recruiting Now Catheter-Associated Urinary Tract Infections (CAUTI): Recruiting August 2025 Ventilator-Associated Pneumonia/Ventilator-Associated Events (VAP/VAE): Recruiting March 2026

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Rockville, MD 20857
Telephone: (301) 427-1364

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